Electrochemical dehydrogenative cross-coupling of xanthenes with ketones.

Authors :: Yang YZ
Wu YC
Song RJ
Li JH
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 Jul 14; Vol. 56 (55), pp. 7585-7588. Date of Electronic Publication: 2020 Jun 08.
Publication Year :: 2020
Abstract: A new external oxidant-free electrochemical dehydrogenative cross-coupling of xanthenes and ketones for the preparation of functionalized 9-alkyl-9H-xanthenes was developed. This method enables the formation of a new C(sp <superscript>3</superscript> )-C(sp <superscript>3</superscript> ) bond through release of H <subscript>2</subscript> as the major byproduct at room temperature, and features mild conditions, high atom economy, excellent functional-group tolerance, scalability and facile applications in pharmaceutical chemistry.