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Amoxicillin-Clavulanate-Induced Ischaemic Colitis.
- Source :
-
Case reports in gastroenterology [Case Rep Gastroenterol] 2020 Apr 29; Vol. 14 (1), pp. 242-247. Date of Electronic Publication: 2020 Apr 29 (Print Publication: 2020). - Publication Year :
- 2020
-
Abstract
- Ischaemic colitis (IC) is the most frequent form of ischaemia of the digestive tract. Due to the worldwide increasing use of medications, there is a growing interest in drug-induced IC. This study reports a rare case of IC directly due to amoxicillin-clavulanate intake. The objective of the study was to describe the evolution of this novel manifestation. An 18-year-old man, non-smoker, with an insignificant medical history, presented with diarrhoea and cramping abdominal pain that started the day following the end of a 10-day amoxicillin-clavulanate course for recent upper respiratory tract infection. Stool cultures including Clostridium difficile toxin testing were negative. Colonoscopy documented an erosive-ulcerative colitis of the sigmoid and the descending colon. Histological examination of the colon biopsies revealed an IC with focal pseudomembranous areas in the descending-sigmoid colon. Thrombophilia screening tests were negative. The patient was discharged from the hospital without symptoms, and another colonoscopy was performed 3 weeks after the previous one, which documented normal endoscopic and histological findings. Amoxicillin-clavulanate IC is a very rare condition and should be suspected once infectious diseases, vascular/haemodynamic causes and a prothrombotic/hypercoagulable state have been excluded. Immediate discontinuation of the antibiotic leads to rapid disease remission.<br />Competing Interests: The authors have no conflicts of interest to declare.<br /> (Copyright © 2020 by S. Karger AG, Basel.)
Details
- Language :
- English
- ISSN :
- 1662-0631
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Case reports in gastroenterology
- Publication Type :
- Report
- Accession number :
- 32508555
- Full Text :
- https://doi.org/10.1159/000507014