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Repetitive negative thinking is associated with amyloid, tau, and cognitive decline.
- Source :
-
Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2020 Jul; Vol. 16 (7), pp. 1054-1064. Date of Electronic Publication: 2020 Jun 07. - Publication Year :
- 2020
-
Abstract
- Introduction: The Cognitive Debt hypothesis proposes that repetitive negative thinking (RNT), a modifiable process common to many psychological risk factors for Alzheimer's disease (AD) may itself increase risk. We sought to empirically examine relationships between RNT and markers of AD, compared with anxiety and depression symptoms.<br />Methods: Two hundred and ninety-two older adults with longitudinal cognitive assessments, including 113 with amyloid-positron emission tomography (PET) and tau-PET scans, from the PREVENT-AD cohort and 68 adults with amyloid-PET scans from the IMAP+ cohort were included. All participants completed RNT, anxiety, and depression questionnaires.<br />Results: RNT was associated with decline in global cognition (P = .02); immediate (P = .03) and delayed memory (P = .04); and global amyloid (PREVENT-AD: P = .01; IMAP+: P = .03) and entorhinal tau (P = .02) deposition. Relationships remained after adjusting for potential confounders.<br />Discussion: RNT was associated with decline in cognitive domains affected early in AD and with neuroimaging AD biomarkers. Future research could investigate whether modifying RNT reduces AD risk.<br /> (© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
- Subjects :
- Aged
Aged, 80 and over
Alzheimer Disease diagnostic imaging
Alzheimer Disease metabolism
Cognitive Dysfunction diagnostic imaging
Cognitive Dysfunction metabolism
Female
Humans
Memory, Short-Term physiology
Middle Aged
Neuropsychological Tests
Positron-Emission Tomography
Risk Factors
Temporal Lobe diagnostic imaging
Alzheimer Disease psychology
Amyloid beta-Peptides metabolism
Cognition physiology
Cognitive Dysfunction psychology
Pessimism psychology
Temporal Lobe metabolism
tau Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1552-5279
- Volume :
- 16
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Alzheimer's & dementia : the journal of the Alzheimer's Association
- Publication Type :
- Academic Journal
- Accession number :
- 32508019
- Full Text :
- https://doi.org/10.1002/alz.12116