Back to Search
Start Over
Effects of intraovarian injection of autologous platelet rich plasma on ovarian reserve and IVF outcome parameters in women with primary ovarian insufficiency.
- Source :
-
Aging [Aging (Albany NY)] 2020 Jun 05; Vol. 12 (11), pp. 10211-10222. Date of Electronic Publication: 2020 Jun 05. - Publication Year :
- 2020
-
Abstract
- We aimed to determine whether intraovarian injection of autologous platelet rich plasma (PRP) improves response to ovarian stimulation and in vitro fertilization (IVF) outcome in women with primary ovarian insufficiency (POI). Women (N=311; age 24-40) diagnosed with POI based on ESHRE criteria underwent intraovarian PRP injection. Markers of ovarian reserve, and IVF outcome parameters were followed. PRP treatment resulted in increased antral follicle count (AFC) and serum antimullerian hormone (AMH), while serum follicle stimulating hormone (FSH) did not change significantly. After PRP injection, 23 women (7.4%) conceived spontaneously, 201 (64.8%) developed antral follicle(s) and attempted IVF, and 87 (27.8%) had no antral follicles and therefore did not receive additional treatment. Among the 201 women who attempted IVF, 82 (26.4% of total) developed embryos; 25 of these women preferred to cryopreserve embryos for transfer at a later stage, while 57 underwent embryo transfer resulting in 13 pregnancies (22.8% per transfer, 4% of total). In total, of the 311 women treated with PRP, 25 (8.0%) achieved livebirth/sustained implantation (spontaneously or after IVF), while another 25 (8.0%) cryopreserved embryos. Our findings suggest that in women with POI, intraovarian injection of autologous PRP might be considered as an alternative experimental treatment option.
- Subjects :
- Adult
Embryo Transfer
Female
Fertilization in Vitro
Humans
Infertility, Female etiology
Live Birth
Ovarian Reserve physiology
Pregnancy
Primary Ovarian Insufficiency therapy
Treatment Outcome
Young Adult
Blood Transfusion, Autologous methods
Infertility, Female therapy
Ovulation Induction methods
Platelet-Rich Plasma physiology
Primary Ovarian Insufficiency complications
Subjects
Details
- Language :
- English
- ISSN :
- 1945-4589
- Volume :
- 12
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Aging
- Publication Type :
- Academic Journal
- Accession number :
- 32507764
- Full Text :
- https://doi.org/10.18632/aging.103403