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Cholinergic dysfunction, neurodegeneration, and amyloid-beta pathology in neurodegenerative diseases.
- Source :
-
Psychiatry research. Neuroimaging [Psychiatry Res Neuroimaging] 2020 Aug 30; Vol. 302, pp. 111099. Date of Electronic Publication: 2020 May 17. - Publication Year :
- 2020
-
Abstract
- Cholinergic dysfunction is central in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). The electroencephalography-based acetylcholine index (EEG-Ach index) has been proposed as a biomarker of cholinergic dysfunction. However, it is unclear how the EEG-Ach index relates to amyloid-beta pathology and neurodegeneration. We investigated the association between the EEG-Ach index and cerebrospinal fluid (CSF) amyloid-beta, CSF total tau, cortical thickness, and hippocampal volume from magnetic resonance imaging (MRI), and cognition. A total of 127 patients with different neurodegenerative diseases were studied. The EEG-Ach index was calculated from quantitative EEG using statistical pattern recognition. The EEG-Ach index was associated with hippocampal volume and cortical thickness in frontal, temporal, and occipital cortices. Cross-sectional sub-analyses based on a small sample suggests that the EEG-Ach index increases the closest to AD dementia, downstream to amyloid-beta pathology, CSF total tau, and hippocampal volume. We conclude that cholinergic dysfunction correlates with atrophy in brain areas important for AD pathogenesis, and this association is more prominent in the dementia stage. These results together with previous studies from this project suggest that the EEG-Ach index may be a useful biomarker for cholinergic dysfunction, with value for differential diagnosis of dementia and monitoring patients at the dementia stage.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- Acetylcholine
Aged
Aged, 80 and over
Alzheimer Disease cerebrospinal fluid
Alzheimer Disease diagnostic imaging
Alzheimer Disease pathology
Amyloid beta-Peptides cerebrospinal fluid
Atrophy
Biomarkers cerebrospinal fluid
Brain diagnostic imaging
Brain pathology
Cerebral Cortex pathology
Cholinergic Antagonists
Cognition
Cross-Sectional Studies
Diagnosis, Differential
Female
Hippocampus pathology
Humans
Lewy Body Disease cerebrospinal fluid
Lewy Body Disease diagnostic imaging
Lewy Body Disease pathology
Magnetic Resonance Imaging
Male
Mental Status and Dementia Tests
Middle Aged
Neurodegenerative Diseases cerebrospinal fluid
Neurodegenerative Diseases diagnostic imaging
Neurodegenerative Diseases pathology
Neurodegenerative Diseases physiopathology
Organ Size
Scopolamine
tau Proteins cerebrospinal fluid
Alzheimer Disease physiopathology
Cerebral Cortex diagnostic imaging
Electroencephalography
Hippocampus diagnostic imaging
Lewy Body Disease physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7506
- Volume :
- 302
- Database :
- MEDLINE
- Journal :
- Psychiatry research. Neuroimaging
- Publication Type :
- Academic Journal
- Accession number :
- 32505903
- Full Text :
- https://doi.org/10.1016/j.pscychresns.2020.111099