Back to Search
Start Over
Cellular complexity in brain organoids: Current progress and unsolved issues.
- Source :
-
Seminars in cell & developmental biology [Semin Cell Dev Biol] 2021 Mar; Vol. 111, pp. 32-39. Date of Electronic Publication: 2020 Jun 01. - Publication Year :
- 2021
-
Abstract
- Brain organoids are three-dimensional neural aggregates derived from pluripotent stem cells through self-organization and recapitulate architectural and cellular aspects of certain brain regions. Brain organoids are currently a highly exciting area of research that includes the study of human brain development, function, and dysfunction in unprecedented ways. In this Review, we discuss recent discoveries related to the generation of brain organoids that resemble diverse brain regions. We provide an overview of the strategies to complement these primarily neuroectodermal models with cell types of non-neuronal origin, such as vasculature and immune cells. Recent transplantation approaches aiming to achieve higher cellular complexity and long-term survival of these models will then be discussed. We conclude by highlighting unresolved key questions and future directions in this exciting area of human brain organogenesis.<br /> (Copyright © 2020 Elsevier Ltd. All rights reserved.)
- Subjects :
- Brain physiology
Cell Differentiation
Cell Transplantation methods
Cell Transplantation trends
Endothelial Cells cytology
Endothelial Cells physiology
Humans
Lymphocytes cytology
Lymphocytes physiology
Models, Biological
Neovascularization, Physiologic
Neural Stem Cells physiology
Neural Stem Cells transplantation
Neurogenesis physiology
Neuroglia cytology
Neuroglia physiology
Neurons physiology
Neurons transplantation
Organoids physiology
Pluripotent Stem Cells physiology
Brain cytology
Neural Stem Cells cytology
Neurons cytology
Organoids cytology
Pluripotent Stem Cells cytology
Subjects
Details
- Language :
- English
- ISSN :
- 1096-3634
- Volume :
- 111
- Database :
- MEDLINE
- Journal :
- Seminars in cell & developmental biology
- Publication Type :
- Academic Journal
- Accession number :
- 32499191
- Full Text :
- https://doi.org/10.1016/j.semcdb.2020.05.013