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A facile sonochemical protocol for synthesis of 3-amino- and 4-amino-1,2,4-triazole derived Schiff bases as potential antibacterial agents.
- Source :
-
PloS one [PLoS One] 2020 Jun 04; Vol. 15 (6), pp. e0229891. Date of Electronic Publication: 2020 Jun 04 (Print Publication: 2020). - Publication Year :
- 2020
-
Abstract
- A facile method has been developed for the synthesis of Schiff bases derived from substituted and unsubstituted 3-amino- and 4-amino-1,2,4-triazoles. Condensation of the aminotrizoles with a variety of aromatic aldehydes afforded desired Schiff bases in excellent yields in 3-5 minutes of exposure to ultra-sound. The synthesized compounds were characterized by means of IR, 1HNMR and Mass spectrometry. The synthesized compounds were also screened for their antibacterial potential against Gram-negative (Escherichia coli, Shigella sonnei, Pseudomonas aeruginosa and Salmonella typhi) and two Gram-positive (Staphylococcus aureus and Bacillus subtilis) strains.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Amitrole chemistry
Anti-Bacterial Agents chemistry
Bacteria drug effects
Chemistry Techniques, Synthetic
Microbial Sensitivity Tests
Schiff Bases chemistry
Triazoles chemistry
Amitrole chemical synthesis
Amitrole pharmacology
Anti-Bacterial Agents chemical synthesis
Anti-Bacterial Agents pharmacology
Triazoles chemical synthesis
Triazoles pharmacology
Ultrasonic Waves
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 15
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 32497076
- Full Text :
- https://doi.org/10.1371/journal.pone.0229891