Back to Search Start Over

A facile sonochemical protocol for synthesis of 3-amino- and 4-amino-1,2,4-triazole derived Schiff bases as potential antibacterial agents.

Authors :
Sultan A
Ur Rehman MH
Sajjad N
Irfan A
Ullah I
Mustaqeem M
Saleem M
Rubab SL
Rafiq M
Khalid M
Kotwica-Mojzych K
Mojzych M
Source :
PloS one [PLoS One] 2020 Jun 04; Vol. 15 (6), pp. e0229891. Date of Electronic Publication: 2020 Jun 04 (Print Publication: 2020).
Publication Year :
2020

Abstract

A facile method has been developed for the synthesis of Schiff bases derived from substituted and unsubstituted 3-amino- and 4-amino-1,2,4-triazoles. Condensation of the aminotrizoles with a variety of aromatic aldehydes afforded desired Schiff bases in excellent yields in 3-5 minutes of exposure to ultra-sound. The synthesized compounds were characterized by means of IR, 1HNMR and Mass spectrometry. The synthesized compounds were also screened for their antibacterial potential against Gram-negative (Escherichia coli, Shigella sonnei, Pseudomonas aeruginosa and Salmonella typhi) and two Gram-positive (Staphylococcus aureus and Bacillus subtilis) strains.<br />Competing Interests: The authors have declared that no competing interests exist.

Details

Language :
English
ISSN :
1932-6203
Volume :
15
Issue :
6
Database :
MEDLINE
Journal :
PloS one
Publication Type :
Academic Journal
Accession number :
32497076
Full Text :
https://doi.org/10.1371/journal.pone.0229891