Ellagitannins and simple phenolics from the halophytic plant Tamarix nilotica .

Three new [nilotinins M8‒M10 ( 1 ‒ 3 )] and two known [tamarixinin A ( 4 ) and gemin D ( 5 )] ellagitannins and seven simple phenolics [gallic acid ( 6 ), methyl gallate ( 7 ), 3,4-di- O -methylgallic acid ( 8 ), ellagic acid ( 9 ), 3- O -methylellagic acid ( 10 ), methyl ferulate 3- O -sulphate ( 11 ), and 7,4'-di- O -methylkaempferol ( 12 )] were isolated from the halophytic plant Tamarix nilotica (Ehrenb.) Bunge (Tamaricaceae). Their structures were determined based on intensive spectroscopic studies and comparisons with reported data. Compounds 4 , and 6 - 8 were evaluated for their cytotoxicity against lung adenocarcinoma cell line (A549) and anti-leishmanial activity against Leishmania major . Compounds 4 , 6 and 7 showed promising cytotoxic properties against A549 (IC ₅₀ 29 ± 2.3, 10.5 ± 0.7, and 20.7 ± 1.9 μg/mL), while compounds 4 and 7 showed higher growth-inhibitory effects against L. major promastigotes (IC ₅₀ 40.5 ± 2.7 and 38.4 ± 2.5 μg/mL), as compared with the standards doxorubicin (IC ₅₀ 0.42 µg/mL) and miltefosine (IC ₅₀ 9.43 μg/mL), respectively.