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Multiple-dose versus single-dose gonadotropin-releasing hormone agonist after first in vitro fertilization failure associated with luteal phase deficiency: A randomized controlled trial.
- Source :
-
The Journal of international medical research [J Int Med Res] 2020 Jun; Vol. 48 (6), pp. 300060520926026. - Publication Year :
- 2020
-
Abstract
- Objective: To evaluate the efficacy and safety of multiple- versus single-dose gonadotropin-releasing hormone agonist (GnRH-a) addition to luteal phase support (LPS), in patients with a first in vitro fertilization (IVF) failure associated with luteal phase deficiency (LPD).<br />Methods: Eighty patients with a first IVF failure associated with LPD were randomly assigned into single-dose and multiple-dose GnRH-a groups. In the second IVF attempt, patients in the single-dose group were given standard LPS plus a single dose of GnRH-a 6 days after oocyte retrieval. Patients in the multiple-dose group received standard LPS plus 14 daily injections of GnRH-a. Children conceived were followed up for 2 years.<br />Results: Pregnancy (67.5% vs. 42.5%), clinical pregnancy (50.0% vs. 22.5%), and live birth rates (42.5% vs. 20.0%) were significantly higher in the multiple-dose versus single-dose GnRH-a group. Patients in the multiple-dose GnRH-a group had significantly higher progesterone levels 14 days after oocyte recovery (35.9 vs. 21.4 ng/mL). No significant difference existed in the status at birth or developmental and behavior assessments of 2-year-old children conceived in both groups.<br />Conclusions: Daily addition of GnRH-a to standard LPS can achieve better pregnancy outcomes with a sustained safety profile in patients with a first IVF failure associated with LPD.
- Subjects :
- Adult
Child, Preschool
Chorionic Gonadotropin administration & dosage
Chorionic Gonadotropin adverse effects
Drug Administration Schedule
Female
Fertility Agents, Female adverse effects
Fertilization in Vitro adverse effects
Follicle Stimulating Hormone, Human administration & dosage
Follicle Stimulating Hormone, Human adverse effects
Follow-Up Studies
Humans
Infant
Infant, Newborn
Infertility, Female blood
Live Birth
Luteal Phase blood
Ovulation Induction adverse effects
Ovulation Induction methods
Pregnancy
Pregnancy Rate
Progesterone blood
Prospective Studies
Recombinant Proteins administration & dosage
Recombinant Proteins adverse effects
Retreatment adverse effects
Retreatment methods
Treatment Outcome
Young Adult
Fertility Agents, Female administration & dosage
Fertilization in Vitro methods
Gonadotropin-Releasing Hormone agonists
Infertility, Female therapy
Luteal Phase drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1473-2300
- Volume :
- 48
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of international medical research
- Publication Type :
- Academic Journal
- Accession number :
- 32495663
- Full Text :
- https://doi.org/10.1177/0300060520926026