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External evaluation of population pharmacokinetic models for continuous administration of meropenem in critically ill adult patients.
- Source :
-
European journal of clinical pharmacology [Eur J Clin Pharmacol] 2020 Sep; Vol. 76 (9), pp. 1281-1289. Date of Electronic Publication: 2020 Jun 04. - Publication Year :
- 2020
-
Abstract
- Purpose: Beta-lactams (BL), the most commonly prescribed class of antibiotics, are recommended as the first-line therapy for multiple indications in infectious disease guidelines. Meropenem (MERO) is frequently used in intensive care units (ICU) to treat bacterial infections with or without sepsis. The pharmacokinetics of MERO display a large variability in patients admitted to ICUs due to altered pathophysiology. The aim of this study was to perform an external evaluation of published population pharmacokinetic models of MERO in order to test their predictive performance in a cohort of ICU adult patients.<br />Methods: A literature search in PubMed/Medline database was made following the PRISMA statement. External evaluation was performed using NONMEM software, and the bias and inaccuracy values were calculated.<br />Results: An external validation dataset from the Timone Hospital in Marseille, France, included 84 concentration samples from 27 patients. Four models of MERO were identified according to the inclusion criteria of the study. None of the models presented acceptable values of bias and inaccuracy.<br />Conclusion: While performing external evaluations on some populations may confirm a model's suitability to diverse groups of patients, there is still some variability that cannot be explained nor solved by the procedure. This brings to light the difficulty to develop only one model for ICU patients and the need to develop one specific model to each population of critically ill patients.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents administration & dosage
Critical Illness
Female
Humans
Male
Meropenem administration & dosage
Middle Aged
Prospective Studies
Young Adult
Anti-Bacterial Agents pharmacokinetics
Intensive Care Units
Meropenem pharmacokinetics
Models, Biological
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1041
- Volume :
- 76
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- European journal of clinical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 32495084
- Full Text :
- https://doi.org/10.1007/s00228-020-02922-z