Back to Search
Start Over
Lactobacillus plantarum KFY04 prevents obesity in mice through the PPAR pathway and alleviates oxidative damage and inflammation.
- Source :
-
Food & function [Food Funct] 2020 Jun 24; Vol. 11 (6), pp. 5460-5472. - Publication Year :
- 2020
-
Abstract
- In this study, lactic acid bacterium, Lactobacillus plantarum KFY04, was isolated from Xinjiang yogurt, and it was used to intervene in obese mice maintained on a 45% fat diet, and we compared its effects to those of a commercial strain, LDSB, and l-carnitine. The results showed that the LP-KFY04 intervention mice gained weight more slowly and had lower liver, epididymal adipose, and perirenal adipose tissue indices when compared to the other high-fat groups. Moreover, the LP-KFY04 can reduce the formation of fat vacuoles in the liver, while also reducing adipocyte differentiation and volume, and LP-KFY04 groups had the lowest liver and serum AST, ALT, TG, and TC levels and lowest serum LDL-C and highest HDL-C levels among the groups maintained on a high-fat diet. LP-KFY04 was also shown to mitigate obesity-associated oxidative damage and inflammatory responses. Additionally, quantitative real-time PCR and western blot analysis examining liver and adipose tissue expression of PPAR-α, CYP7A1, CPT1, and LPL showed an increased expression in the LP-KFY04 groups while decreased expression levels of PPAR-γ and C/EBPα relative to the other high-fat diet groups. These results show that of the different interventions, LP-KFY04 was the most effective at mitigating the effects of obesity than LDSB and l-carnitine. The results confirmed that LP-KEY04 has better anti-obesity, anti-oxidative, and anti-inflammatory effects than current fermentation strains. It indicates LP-KFY04 is a fermentation strain with potential practical value and high functionality, and it shows that a fermentation strain should not only have good fermentation performance, but, more importantly, it must provide more functionality on the basis of fermentation.
- Subjects :
- Adipose Tissue metabolism
Adipose Tissue pathology
Animals
Body Weight
Cholesterol 7-alpha-Hydroxylase metabolism
Cytokines blood
Diet, High-Fat adverse effects
Epididymis
Female
Liver metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Obese
PPAR alpha metabolism
Yogurt
Inflammation metabolism
Lactobacillus plantarum physiology
Obesity metabolism
Obesity prevention & control
Oxidative Stress
Subjects
Details
- Language :
- English
- ISSN :
- 2042-650X
- Volume :
- 11
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Food & function
- Publication Type :
- Academic Journal
- Accession number :
- 32490861
- Full Text :
- https://doi.org/10.1039/d0fo00519c