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A Microarray Screening Platform with an Experimental Conditions Gradient Generator for the High-Throughput Synthesis of Micro/Nanosized Calcium Phosphates.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2020 May 30; Vol. 21 (11). Date of Electronic Publication: 2020 May 30. - Publication Year :
- 2020
-
Abstract
- Calcium phosphates (CaP) represent an impressive kind of biomedical material due to their excellent biocompatibility, bioactivity, and biodegradability. Their morphology and structure highly influence their properties and applications. Whilst great progress has been made in research on biomedical materials, there is still a need to develop a method that can rapidly synthesize and screen micro/nanosized biomedical materials. Here, we utilized a microarray screening platform that could provide the high-throughput synthesis of biomedical materials and screen the vital reaction conditions. With this screening platform, 9 × 9 sets of parallel experiments could be conducted simultaneously with one- or two-dimensions of key reaction condition gradients. We used this platform to establish a one-dimensional gradient of the pH and citrate concentration and a two-dimensional gradient of both the Ca/P ratio and pH to synthesize CaP particles with various morphologies. This screening platform also shows the potential to be extended to other reaction systems for rapid high-throughput screening.
- Subjects :
- Dimethylpolysiloxanes chemistry
High-Throughput Screening Assays methods
Hydrogen-Ion Concentration
Materials Testing
Microfluidics
Microscopy, Electron, Scanning
Polymethyl Methacrylate chemistry
Spectroscopy, Fourier Transform Infrared
X-Ray Diffraction
Biocompatible Materials chemistry
Calcium Phosphates chemistry
High-Throughput Screening Assays instrumentation
Nanoparticles chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 21
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 32486293
- Full Text :
- https://doi.org/10.3390/ijms21113939