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Factors in B cell competition and immunodominance.
- Source :
-
Immunological reviews [Immunol Rev] 2020 Jul; Vol. 296 (1), pp. 120-131. Date of Electronic Publication: 2020 Jun 01. - Publication Year :
- 2020
-
Abstract
- The majority of all vaccines work by inducing protective antibody responses. The mechanisms by which the B cells responsible for producing protective antibodies are elicited to respond are not well understood. Interclonal B cell competition to complex antigens, particularly in germinal centers, has emerged as an important hurdle in designing effective vaccines. This review will focus on recent advances in understanding the roles of B cell precursor frequency, B cell receptor affinity for antigen, antigen avidity, and other factors that can substantially alter the outcomes of B cell responses to complex antigens. Understanding the interdependence of these fundamental factors that affect B cell responses can inform current vaccine design efforts for pathogens with complex proteins as candidate immunogens such as HIV, influenza, and coronaviruses.<br /> (© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Animals
Antigens metabolism
B-Lymphocytes cytology
Cell Competition genetics
Cell Differentiation immunology
Germinal Center immunology
Germinal Center metabolism
Humans
Receptors, Antigen, B-Cell metabolism
B-Lymphocytes immunology
B-Lymphocytes metabolism
Cell Competition immunology
Immunodominant Epitopes immunology
Immunomodulation
Subjects
Details
- Language :
- English
- ISSN :
- 1600-065X
- Volume :
- 296
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Immunological reviews
- Publication Type :
- Academic Journal
- Accession number :
- 32483855
- Full Text :
- https://doi.org/10.1111/imr.12861