Neuroprotective and Antioxidant Activity of Arachidonoyl Choline, Its Bis-Quaternized Analogues and Other Acylcholines.

Authors :: Akimov MG
Dudina PV
Fomina-Ageeva EV
Gretskaya NM
Bosaya AA
Rudakova EV
Makhaeva GF
Kagarlitsky GO
Eremin SA
Tsetlin VI
Bezuglov VV
Source :: Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2020 Mar; Vol. 491 (1), pp. 93-97. Date of Electronic Publication: 2020 Jun 01.
Publication Year :: 2020
Abstract: The antioxidant activity and protective effect in the toxicity model of H <subscript>2</subscript> O <subscript>2</subscript> were studied for arachidonic (AA-CHOL), docosahexaenoic (DHA-CHOL), linoleic (Ln-CHOL), and oleic (Ol-CHOL) fatty acids, as well as arachidonoyl dicholine (AA-diCHOL) and O-arachidonoyl bistetramethylaminoisopropanol (ABTAP). AA-CHOL, DHA-CHOL and Ln-CHOL provided a 20% increase in cell survival. AA-CHOL, AA-diCHOL, Ol-CHOL, and ABTAP had a radical-scavenging effect in the ABTS test, approximately equal to the activity of a standard radical scavenger Trolox.

Subjects :: 2-Propanol chemistry
Arachidonic Acid chemistry
Cell Line, Tumor
Chromans chemistry
Docosahexaenoic Acids chemistry
Drug Screening Assays, Antitumor
Fatty Acids
Free Radicals chemistry
Humans
Hydrogen Peroxide chemistry
Linoleic Acid chemistry
Oleic Acid chemistry
Antioxidants chemistry
Arachidonic Acids chemistry
Choline chemistry

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