Curcumin-loaded lipid-core nanocapsules attenuates the immune challenge LPS-induced in rats: Neuroinflammatory and behavioral response in sickness behavior.

Authors :: de Gomes MG
Teixeira FEG
de Carvalho FB
Pacheco CO
da Silva Neto MR
Giacomeli R
Ramalho JB
Dos Santos RB
Domingues WB
Campos VF
Haas SE
Source :: Journal of neuroimmunology [J Neuroimmunol] 2020 Aug 15; Vol. 345, pp. 577270. Date of Electronic Publication: 2020 May 23.
Publication Year :: 2020
Abstract: The purpose of current study was to evaluate the effect of curcumin (CUR) loaded lipid-core nanocapsules (CUR-LNC) treatment on neuroinflammatory and behavioral alterations in a model of sickness behavior induced by lipopolysaccharide (LPS) in rats. Rats were treated with CUR-LNC and CUR daily for 14 days. After the last treatments, sickness behavior was induced with LPS. Sickness behavior LPS-induced was confirmed by behavioral tests, an increase in levels of proinflammatory cytokines, decrease in levels of IL-10, overexpression of IDO-1 and IDO-2. In conclusion, CUR-LNC treatment attenuated the neuroinflammatory and behavioral changes caused in sickness behavior model.<br />Competing Interests: Declaration of Competing Interest The authors report no conflicts of interest.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)

Subjects :: Animals
Drug Carriers administration & dosage
Illness Behavior drug effects
Inflammation Mediators antagonists & inhibitors
Inflammation Mediators metabolism
Lipids
Locomotion drug effects
Male
Rats
Rats, Wistar
Curcumin administration & dosage
Illness Behavior physiology
Inflammation Mediators immunology
Lipopolysaccharides toxicity
Locomotion physiology
Nanocapsules administration & dosage

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