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Effect of 1,5-anhydroglucitol levels on culprit plaque rupture in diabetic patients with acute coronary syndrome.
- Source :
-
Cardiovascular diabetology [Cardiovasc Diabetol] 2020 May 30; Vol. 19 (1), pp. 71. Date of Electronic Publication: 2020 May 30. - Publication Year :
- 2020
-
Abstract
- Background: Postprandial hyperglycemia was reported to play a key role in established risk factors of coronary artery diseases (CAD) and cardiovascular events. Serum 1,5-anhydroglucitol (1,5-AG) levels are known to be a clinical marker of short-term postprandial glucose (PPG) excursions. Low serum 1,5-AG levels have been associated with occurrence of CAD. However, the relationship between 1,5-AG levels and coronary plaque rupture has not been fully elucidated. The aim of this study was to evaluate 1,5-AG as a predictor of coronary plaque rupture in diabetic patients with acute coronary syndrome (ACS).<br />Methods: A total of 144 diabetic patients with ACS were included in this study. All patients underwent intravascular ultrasound examination, which revealed 49 patients with plaque rupture and 95 patients without plaque rupture in the culprit lesion. Fasting blood glucose (FBG), hemoglobin A <subscript>1c</subscript> (HbA <subscript>1c</subscript> ) and 1,5-AG levels were measured before coronary angiography. Fasting urinary 8-iso-prostaglandin F <subscript>2α</subscript> (8-iso-PGF <subscript>2α</subscript> ) level was measured and corrected by creatinine clearance.<br />Results: Patients with ruptured plaque had significantly lower serum 1,5-AG levels, longer duration of diabetes, higher HbA <subscript>1c</subscript> and FBG levels than patients without ruptured plaque in our study population. In multivariate analysis, low 1,5-AG levels were an independent predictor of plaque rupture (odds ratio 3.421; P = 0.005) in diabetic patients with ACS. The area under the receiver-operating characteristic curve for 1,5-AG (0.658, P = 0.002) to predict plaque rupture was superior to that for HbA <subscript>1c</subscript> (0.587, P = 0.087). Levels of 1,5-AG were significantly correlated with urinary 8-iso-prostaglandin F <subscript>2α</subscript> levels (r = - 0.234, P = 0.005).<br />Conclusions: Serum 1,5-AG may identify high risk for coronary plaque rupture in diabetic patients with ACS, which suggests PPG excursions are related to the pathogenesis of plaque rupture in diabetes.
- Subjects :
- Acute Coronary Syndrome diagnostic imaging
Acute Coronary Syndrome urine
Aged
Biomarkers blood
Biomarkers urine
Blood Glucose metabolism
Coronary Artery Disease diagnostic imaging
Coronary Artery Disease urine
Diabetes Mellitus, Type 2 diagnosis
Diabetes Mellitus, Type 2 urine
Dinoprost analogs & derivatives
Dinoprost urine
Female
Glycated Hemoglobin metabolism
Humans
Male
Middle Aged
Predictive Value of Tests
Prospective Studies
Rupture, Spontaneous
Acute Coronary Syndrome blood
Coronary Artery Disease blood
Coronary Vessels diagnostic imaging
Deoxyglucose blood
Diabetes Mellitus, Type 2 blood
Plaque, Atherosclerotic
Ultrasonography, Interventional
Subjects
Details
- Language :
- English
- ISSN :
- 1475-2840
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cardiovascular diabetology
- Publication Type :
- Academic Journal
- Accession number :
- 32473648
- Full Text :
- https://doi.org/10.1186/s12933-020-01045-0