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Oridonin induces the apoptosis of mucoepidermoid carcinoma cell lines in a myeloid cell leukemia‑1‑dependent manner.
- Source :
-
International journal of oncology [Int J Oncol] 2020 Jul; Vol. 57 (1), pp. 377-385. Date of Electronic Publication: 2020 May 07. - Publication Year :
- 2020
-
Abstract
- Oridonin, an active diterpenoid isolated from Rabdosia rubescens, has been reported to exhibit anticancer activities in several tumors. The aim of the present study was to investigate the anticancer effects and molecular mechanisms of oridonin in mucoepidermoid carcinoma (MEC). Treatment with oridonin induced the apoptosis of MC‑3 and YD‑15 cell and inhibited the expression of myeloid cell leukemia‑1 (MCL‑1) through the regulation of the protein level through post‑translational regulation in these cell lines. Oridonin significantly increased the expression level of truncated Bid (t‑Bid) as a downstream target of MCL‑1 and subsequently decreased the mitochondrial membrane potential. The ectopic expression of MCL‑1 protein was sufficient to reverse the induction of apoptosis and the increased t‑Bid expression induced by oridonin in both cell lines. Taken together, these results suggest that oridonin exerts an apoptotic effect through the modulation of MCL‑1 and t‑Bid in human MEC cell lines and may thus be a potential anticancer drug candidate for the treatment of human MEC.
- Subjects :
- BH3 Interacting Domain Death Agonist Protein metabolism
Carcinoma, Mucoepidermoid metabolism
Cell Line, Tumor
Cell Survival drug effects
Humans
Membrane Potential, Mitochondrial drug effects
Myeloid Cell Leukemia Sequence 1 Protein genetics
Protein Processing, Post-Translational drug effects
Signal Transduction drug effects
Antineoplastic Agents, Phytogenic pharmacology
Apoptosis drug effects
Carcinoma, Mucoepidermoid pathology
Diterpenes, Kaurane pharmacology
Myeloid Cell Leukemia Sequence 1 Protein metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1791-2423
- Volume :
- 57
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of oncology
- Publication Type :
- Academic Journal
- Accession number :
- 32467983
- Full Text :
- https://doi.org/10.3892/ijo.2020.5061