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Pd-Catalyzed Dearomative Asymmetric Allylic Alkylation of Naphthols with Alkoxyallenes.
- Source :
-
The Journal of organic chemistry [J Org Chem] 2020 Jun 19; Vol. 85 (12), pp. 7896-7904. Date of Electronic Publication: 2020 Jun 05. - Publication Year :
- 2020
-
Abstract
- A Pd-catalyzed linear selective intermolecular asymmetric dearomative allylic alkylation reaction of naphthols with alkoxyallenes under mild reaction conditions is reported. The transformation is successfully promoted by Pd <subscript>2</subscript> (dba) <subscript>3</subscript> and the chiral Trost ligand and provides a general atom-efficient protocol to obtain various β-naphthalenones bearing an all carbon quaternary stereogenic center in good yields and chemo- and stereoselectivities.
Details
- Language :
- English
- ISSN :
- 1520-6904
- Volume :
- 85
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The Journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 32466648
- Full Text :
- https://doi.org/10.1021/acs.joc.0c00582