Back to Search
Start Over
Macrothrombosis and stroke in patients with mild Covid-19 infection.
- Source :
-
Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2020 Aug; Vol. 18 (8), pp. 2031-2033. Date of Electronic Publication: 2020 Jun 25. - Publication Year :
- 2020
-
Abstract
- Coronavirus disease 2019 (COVID-19) is a pandemic disease currently affecting millions of people worldwide. Its neurological implications are poorly understood, and further study is urgently required. A hypercoagulable state has been reported in patients with severe COVID-19, but nothing is known about coagulopathy in patients with milder disease. We describe cases of patients in New York City presenting with stroke secondary to large vessel thrombosis without occlusion, incidentally found to have COVID-19 with only mild respiratory symptoms. This is in contrast to the venous thrombosis and microangiopathy that has been reported in patients with severe COVID-19. Our cases suggest that even in the absence of severe disease, patients with COVID-19 may be at increased risk of thrombus formation leading to stroke, perhaps resulting from viral involvement of the endothelium. Further systematic study is needed because this may have implications for primary and secondary stroke prevention in patients with COVID-19.<br /> (© 2020 International Society on Thrombosis and Haemostasis.)
- Subjects :
- Adult
Aged
Anticoagulants therapeutic use
Biomarkers
C-Reactive Protein analysis
COVID-19
Carotid Artery Thrombosis blood
Carotid Artery Thrombosis diagnostic imaging
Carotid Artery Thrombosis drug therapy
Cerebral Angiography
Computed Tomography Angiography
Coronavirus Infections blood
Coronavirus Infections diagnosis
Coronavirus Infections epidemiology
Emergencies
Female
Fibrin Fibrinogen Degradation Products analysis
Hemiplegia etiology
Humans
Infarction, Middle Cerebral Artery blood
Infarction, Middle Cerebral Artery diagnostic imaging
Infarction, Middle Cerebral Artery drug therapy
Magnetic Resonance Angiography
Male
Middle Aged
New York City epidemiology
Pneumonia, Viral blood
Pneumonia, Viral diagnosis
Pneumonia, Viral epidemiology
SARS-CoV-2
Thrombophlebitis complications
Betacoronavirus isolation & purification
Carotid Artery Thrombosis etiology
Coronavirus Infections complications
Infarction, Middle Cerebral Artery etiology
Pandemics
Pneumonia, Viral complications
Subjects
Details
- Language :
- English
- ISSN :
- 1538-7836
- Volume :
- 18
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of thrombosis and haemostasis : JTH
- Publication Type :
- Report
- Accession number :
- 32464707
- Full Text :
- https://doi.org/10.1111/jth.14938