Does the breakdown of the detoxification system for aldehydes as a result of aldose reductase upregulation lead to alcohol-induced liver injury in humans and mice?

Authors :: Hotta N
Kawamura T
Umemura T
Source :: Journal of diabetes investigation [J Diabetes Investig] 2020 Nov; Vol. 11 (6), pp. 1426-1430. Date of Electronic Publication: 2020 Jul 07.
Publication Year :: 2020

Subjects :: Aldehyde Reductase genetics
Animals
Central Nervous System Depressants toxicity
Chemical and Drug Induced Liver Injury, Chronic etiology
Chemical and Drug Induced Liver Injury, Chronic metabolism
Humans
Mice
Up-Regulation
Aldehyde Reductase metabolism
Aldehydes metabolism
Chemical and Drug Induced Liver Injury, Chronic pathology
Ethanol toxicity

Full Text Access

Tools