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Unilateral acute anterior uveitis is associated with ipsilateral changes in the tear fluid proteome that involves the LXR/RXR pathway.

Unilateral acute anterior uveitis is associated with ipsilateral changes in the tear fluid proteome that involves the LXR/RXR pathway.

Authors :
Eidet JR
Jørstad ØK
Fostad IG
Olstad OK
Sørland RØ
Moe MC
Petrovski G
Pepaj M
Source :
Journal of ophthalmic inflammation and infection [J Ophthalmic Inflamm Infect] 2020 May 27; Vol. 10 (1), pp. 13. Date of Electronic Publication: 2020 May 27.
Publication Year :
2020

Abstract

Purpose: To determine whether unilateral acute anterior uveitis (AAU) induces ipsilateral changes in the tear fluid proteome.<br />Methods: Five patients (25-77 years old) with unilateral AAU were included. Tear fluid samples were obtained using Schirmer's test strips. The healthy eye served as control. Proteins were identified by liquid chromatography tandem mass spectrometry.<br />Results: Two hundred forty-two tear fluid sample proteins were identified, of which 75 were present in at least three patients. Nine proteins were at least 1.5-fold increased, whereas eight were at least 1.5-fold decreased in tears from the diseased eye compared with the healthy eye. APOBEC3A was significantly increased (1.43-fold; P = 0.04), whereas TGM2 was significantly decreased (- 1.21-fold; P = 0.03) in tears from the diseased eye relative to the healthy eye. Ingenuity Pathway Analysis identified LXR/RXR (P < 1.02E-4) as a top canonical pathway.<br />Conclusion: Unilateral AAU induced detectable changes in the ipsilateral tear fluid proteome and involvement of the inflammation-associated LXR/RXR pathway.

Details

Language :
English
ISSN :
1869-5760
Volume :
10
Issue :
1
Database :
MEDLINE
Journal :
Journal of ophthalmic inflammation and infection
Publication Type :
Academic Journal
Accession number :
32458144
Full Text :
https://doi.org/10.1186/s12348-020-00204-4