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Arene-Ruthenium(II) Complexes Containing 11 H -Indeno[1,2- b ]quinoxalin-11-one Derivatives and Tryptanthrin-6-oxime: Synthesis, Characterization, Cytotoxicity, and Catalytic Transfer Hydrogenation of Aryl Ketones.

Authors :
Matveevskaya VV
Pavlov DI
Sukhikh TS
Gushchin AL
Ivanov AY
Tennikova TB
Sharoyko VV
Baykov SV
Benassi E
Potapov AS
Source :
ACS omega [ACS Omega] 2020 May 07; Vol. 5 (19), pp. 11167-11179. Date of Electronic Publication: 2020 May 07 (Print Publication: 2020).
Publication Year :
2020

Abstract

A series of novel mono- and binuclear arene-ruthenium(II) complexes [( p -cym)Ru(L)Cl] containing 11 H -indeno[1,2- b ]quinoxalin-11-one derivatives or tryptanthrin-6-oxime were synthesized and characterized by X-ray crystallography, IR, NMR spectroscopy, cyclic voltammetry, and elemental analysis. Theoretical calculations invoking singlet state geometry optimization, solvation effects, and noncovalent interactions were done using density functional theory (DFT). DFT calculations were also applied to evaluate the electronic properties, and time-dependent DFT was applied to clarify experimental UV-vis results. Cytotoxicity for cancerous and noncancerous human cell lines was evaluated with cell viability MTT assay. Complexes demonstrated a moderate cytotoxic effect toward cancerous human cell line PANC-1. The catalytic activity of the complexes was evaluated in transfer hydrogenation of aryl ketones. All complexes exhibited good catalytic activity and functional group tolerance.<br />Competing Interests: The authors declare no competing financial interest.<br /> (Copyright © 2020 American Chemical Society.)

Details

Language :
English
ISSN :
2470-1343
Volume :
5
Issue :
19
Database :
MEDLINE
Journal :
ACS omega
Publication Type :
Academic Journal
Accession number :
32455240
Full Text :
https://doi.org/10.1021/acsomega.0c01204