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NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells.
- Source :
-
The Journal of experimental medicine [J Exp Med] 2020 Aug 03; Vol. 217 (8). - Publication Year :
- 2020
-
Abstract
- NKG2D is a danger sensor expressed on different subsets of innate and adaptive lymphocytes. Despite its established role as a potent activator of the immune system, NKG2D-driven regulation of CD4+ T helper (Th) cell-mediated immunity remains unclear. In this study, we demonstrate that NKG2D modulates Th1 and proinflammatory T-bet+ Th17 cell effector functions in vitro and in vivo. In particular, NKG2D promotes higher production of proinflammatory cytokines by Th1 and T-bet+ Th17 cells and reinforces their transcription of type 1 signature genes, including Tbx21. Conditional deletion of NKG2D in T cells impairs the ability of antigen-specific CD4+ T cells to promote inflammation in vivo during antigen-induced arthritis and experimental autoimmune encephalomyelitis, indicating that NKG2D is an important target for the amelioration of Th1- and Th17-mediated chronic inflammatory diseases.<br />Competing Interests: Disclosures: The authors declare no competing interests exist.<br /> (© 2020 Babic et al.)
- Subjects :
- Animals
Arthritis, Experimental genetics
Arthritis, Experimental pathology
Cytokines genetics
Cytokines immunology
Encephalomyelitis, Autoimmune, Experimental genetics
Encephalomyelitis, Autoimmune, Experimental pathology
Inflammation genetics
Inflammation immunology
Inflammation pathology
Mice
Mice, Knockout
NK Cell Lectin-Like Receptor Subfamily K genetics
T-Box Domain Proteins genetics
T-Box Domain Proteins immunology
Th1 Cells pathology
Th17 Cells pathology
Arthritis, Experimental immunology
Encephalomyelitis, Autoimmune, Experimental immunology
NK Cell Lectin-Like Receptor Subfamily K immunology
Th1 Cells immunology
Th17 Cells immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1540-9538
- Volume :
- 217
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The Journal of experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 32453422
- Full Text :
- https://doi.org/10.1084/jem.20190133