New Derivatives from Microbial Transformation of ent-Kaur-16-en-19-oic Acid by Cunninghamella echinulata.

Authors :: Song C
Liu J
Wang H
Li X
Liu B
Zhang M
Shan X
Li H
Gao J
Qin J
Source :: Chemistry & biodiversity [Chem Biodivers] 2020 Jun; Vol. 17 (6), pp. e2000178. Date of Electronic Publication: 2020 May 26.
Publication Year :: 2020
Abstract: Biotransformation of ent-kaur-16-en-19-oic acid using fungus Cunninghamella echinulata resulted in two novel hydroxylated metabolites together with five known compounds. Their structures were elucidated by means of extensive NMR and HR-ESI-MS data analysis. The eight compounds were measured for their cytotoxicity against the human breast carcinoma (MCF-7) and human hepatoblastoma (HepG-2) cell lines. Seven compounds showed no cytotoxicity to the two cell lines. One compound displayed moderate cytotoxicity against HepG-2 and MCF-7 with the IC <subscript>50</subscript> values of 12.6 and 27.1 μM, respectively.<br /> (© 2020 Wiley-VHCA AG, Zurich, Switzerland.)

Subjects :: Cell Survival drug effects
Cunninghamella chemistry
Diterpenes chemistry
Diterpenes metabolism
Hep G2 Cells
Humans
MCF-7 Cells
Magnetic Resonance Spectroscopy
Molecular Conformation
Spectrometry, Mass, Electrospray Ionization
Cunninghamella metabolism

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