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Carboplatin-induced myelosuppression as related to body weight in dogs.
- Source :
-
Veterinary and comparative oncology [Vet Comp Oncol] 2020 Dec; Vol. 18 (4), pp. 804-810. Date of Electronic Publication: 2020 Jun 15. - Publication Year :
- 2020
-
Abstract
- Smaller dogs are known to have an increased risk of chemotherapy-induced myelosuppression for doxorubicin, mitoxantrone and melphalan. This retrospective study aimed to determine if dogs <15 kg and <10 kg experienced greater degrees of myelosuppression following treatment with carboplatin chemotherapy compared with dogs ≥15 kg. One hundred and one dogs treated with carboplatin for a variety of malignancies were retrospectively analysed. Eight dogs (61%) weighing <10 kg, three (38%) weighing 10 kg to <15 kg and 14 (17%) weighing ≥15 kg experienced a grade 3 or 4 neutropenia. Five dogs (38%) weighing <10 kg, two (25%) weighing 10 kg to <15 kg and 13 (16%) weighing ≥15 kg experienced a grade 3 or 4 thrombocytopenia. Dogs <10 kg were significantly more likely to develop a grade 3 or 4 neutropenia following carboplatin than dogs ≥10 kg (3.5 RR; 95% CI, 1.9-6.3; P < .001). Dogs <15 kg were also significantly more likely to develop a grade 3 or 4 neutropenia than dogs ≥15 kg (3 RR; 95% CI, 1.6-5.6; P = .004). Dogs <10 kg were significantly more likely to develop a grade 3 or 4 thrombocytopenia than those dogs ≥10 kg (2.5 RR; 95% CI, 1.1-5.6; P = .006). Hospitalization was significantly more likely for dogs <10 kg vs ≥10 kg (P = .014) as well as for dogs <15 kg vs ≥15 kg (P = .039). This study demonstrates an increased risk of carboplatin-induced myelosuppression in dogs <15 kg, and particularly those <10 kg. This information should be considered by clinicians when making decisions regarding the initial carboplatin dose for smaller canine patients, especially those <15 kg.<br /> (© 2020 John Wiley & Sons Ltd.)
- Subjects :
- Animals
Dogs
Female
Kansas
Male
Neoplasms drug therapy
Neutropenia chemically induced
Retrospective Studies
Risk Factors
Thrombocytopenia chemically induced
Antineoplastic Agents adverse effects
Body Weight
Carboplatin adverse effects
Dog Diseases drug therapy
Neoplasms veterinary
Neutropenia veterinary
Thrombocytopenia veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 1476-5829
- Volume :
- 18
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Veterinary and comparative oncology
- Publication Type :
- Academic Journal
- Accession number :
- 32452107
- Full Text :
- https://doi.org/10.1111/vco.12622