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Mitochondrial Stress Response and Cancer.
- Source :
-
Trends in cancer [Trends Cancer] 2020 Aug; Vol. 6 (8), pp. 688-701. Date of Electronic Publication: 2020 May 22. - Publication Year :
- 2020
-
Abstract
- Cancer cells survive and adapt to many types of stress including hypoxia, nutrient deprivation, metabolic, and oxidative stress. These stresses are sensed by diverse cellular signaling processes, leading to either degradation of mitochondria or alleviation of mitochondrial stress. This review discusses signaling during sensing and mitigation of stress involving mitochondrial communication with the endoplasmic reticulum, and how retrograde signaling upregulates the mitochondrial stress response to maintain mitochondrial integrity. The importance of the mitochondrial unfolded protein response, an emerging pathway that alleviates cellular stress, will be elaborated with respect to cancer. Detailed understanding of cellular pathways will establish mitochondrial stress response as a key mechanism for cancer cell survival leading to cancer progression and resistance, and provide a potential therapeutic target in cancer.<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Subjects :
- Activating Transcription Factors metabolism
Antineoplastic Agents therapeutic use
Cell Survival drug effects
Chaperonin 60 metabolism
Disease Progression
Drug Resistance, Neoplasm drug effects
Endoplasmic Reticulum drug effects
Endoplasmic Reticulum pathology
Endoplasmic Reticulum Stress drug effects
Humans
Mitochondria drug effects
Mitochondrial Proteins metabolism
Neoplasms drug therapy
Oxidative Stress drug effects
Reactive Oxygen Species metabolism
Signal Transduction drug effects
Antineoplastic Agents pharmacology
Mitochondria pathology
Neoplasms pathology
Unfolded Protein Response drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 2405-8025
- Volume :
- 6
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Trends in cancer
- Publication Type :
- Academic Journal
- Accession number :
- 32451306
- Full Text :
- https://doi.org/10.1016/j.trecan.2020.04.009