Controlled Transdermal Release of Antioxidant Ferulate by a Porous Sc(III) MOF.

Authors :: Osorio-Toribio G
Velásquez-Hernández MJ
Mileo PGM
Zárate JA
Aguila-Rosas J
Leyva-Gómez G
Sánchez-Sánchez R
Magaña JJ
Pérez-Díaz MA
Lázaro IA
Forgan RS
Maurin G
Lima E
Ibarra IA
Source :: IScience [iScience] 2020 Jun 26; Vol. 23 (6), pp. 101156. Date of Electronic Publication: 2020 May 11.
Publication Year :: 2020
Abstract: The Sc(III) MOF-type MFM-300(Sc) is demonstrated in this study to be stable under physiological conditions (PBS), biocompatible (to human skin cells), and an efficient drug carrier for the long-term controlled release (through human skin) of antioxidant ferulate. MFM-300(Sc) also preserves the antioxidant pharmacological effects of ferulate while enhancing the bio-preservation of dermal skin fibroblasts, during the delivery process. These discoveries pave the way toward the extended use of Sc(III)-based MOFs as drug delivery systems (DDSs).<br />Competing Interests: Declaration of Interests The authors declare no competing interests.<br /> (Crown Copyright © 2020. Published by Elsevier Inc. All rights reserved.)