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Chemical Profile, In Vitro Enzyme Inhibitory, and Antioxidant Properties of Stereum Species (Agaricomycetes) from Turkey.
- Source :
-
International journal of medicinal mushrooms [Int J Med Mushrooms] 2019; Vol. 21 (11), pp. 1075-1087. - Publication Year :
- 2019
-
Abstract
- Recently, mushroom species have been the focus of researchers' interest because of several bioactivities. The aim of this study was to investigate the chemical profile and biological activities of various extracts of two Stereum species (S. rugosum and S. sanguinolentum). Antioxidant activity was tested using β-carotene-linoleic acid, DPPH scavenging, ABTS·+ scavenging, cupric-reducing antioxidant capacity (CUPRAC), and metal chelating assays. The extracts were also tested for their enzyme inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). HPLC-DAD was applied for the analysis of phenolic compounds, and fatty acid compositions were determined using GC and GC-MS. When fumaric acid and catechin hydrate were found as the most abundant phenolic compounds in both Stereum species, oleic acid and palmitic acid were identified as major fatty acids. Both of the studied Stereum methanol extracts were determined as the most active in β-carotene-linoleic acid, DPPR, ABTS·+, and CUPRAC assays; the n-hexane extracts were found to be most active in metal chelating and AChE inhibitory activity assays. In addition, the methanol extract of S. sanguinolentum (IC50: 34.26 ± 0.31 μg/mL) showed higher ABTS·+ scavenging activity than α-tocopherol (IC50: 38.51 ± 0.54 μg/mL). The acetone extracts were found as potent inhibitors against BChE. These results suggest that Stereum species could be an antioxidant source and cholinesterase agent in pharmaceutic, food, and cosmetics industries.
- Subjects :
- Antioxidants analysis
Basidiomycota isolation & purification
Biological Factors analysis
Biological Products analysis
Chromatography, High Pressure Liquid
Complex Mixtures isolation & purification
Enzyme Inhibitors analysis
Gas Chromatography-Mass Spectrometry
Inhibitory Concentration 50
Turkey
Antioxidants pharmacology
Basidiomycota chemistry
Biological Factors pharmacology
Biological Products pharmacology
Complex Mixtures chemistry
Enzyme Inhibitors pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1940-4344
- Volume :
- 21
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- International journal of medicinal mushrooms
- Publication Type :
- Academic Journal
- Accession number :
- 32450017
- Full Text :
- https://doi.org/10.1615/IntJMedMushrooms.2019032893