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Proteomic applications in pathology and laboratory medicine: Present state and future prospects.
- Source :
-
Clinical biochemistry [Clin Biochem] 2020 Aug; Vol. 82, pp. 12-20. Date of Electronic Publication: 2020 May 19. - Publication Year :
- 2020
-
Abstract
- Clinical mass spectrometry applications have traditionally focused on small molecules, particularly in the areas of therapeutic drug monitoring, toxicology, and measurement of endogenous and exogenous steroids. More recently, the use of matrix assisted laser desorption/ionization time of flight mass spectrometry for the identification of microbial pathogens has been widely implemented. Following this evolution, there has been an expanding role for the measurement of peptides and proteins in pathology and laboratory medicine. This review explores the current state of protein measurement by clinical mass spectrometry and the analytical strategies employed, as well as emerging applications in clinical chemistry, clinical microbiology and anatomical pathology.<br /> (Copyright © 2020 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Chemistry, Clinical methods
Chromatography, Liquid methods
Drug Monitoring methods
Forecasting
Humans
Immunoprecipitation methods
Microbiological Techniques
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization methods
Tandem Mass Spectrometry methods
Diagnostic Tests, Routine methods
Diagnostic Tests, Routine trends
Pathology methods
Proteomics methods
Proteomics trends
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2933
- Volume :
- 82
- Database :
- MEDLINE
- Journal :
- Clinical biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 32442429
- Full Text :
- https://doi.org/10.1016/j.clinbiochem.2020.05.007