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Is there an association between serum 25(OH)D 3 and mental well-being in patients with type 2 diabetes? Results from a cohort study in primary care.

Authors :
Samefors M
Scragg R
Nystrom FH
Östgren CJ
Source :
Hormones (Athens, Greece) [Hormones (Athens)] 2020 Sep; Vol. 19 (3), pp. 361-367. Date of Electronic Publication: 2020 May 21.
Publication Year :
2020

Abstract

Purpose: There are limited and inconsistent results on the correlation between vitamin D and mental health in patients with type 2 diabetes (T2D). Thus, our aim was to explore the association between vitamin D and mental well-being in a community-based sample of participants with T2D.<br />Methods: We analyzed serum 25-hydroxyvitamin D <subscript>3</subscript> (25(OH)D <subscript>3</subscript> ) in 698 patients with T2D at the baseline examination. The cohort was reinvestigated after 4 years. Data from SF-36 questionnaires measuring vitality and mental health at baseline and after 4 years were used for analyses.<br />Results: Serum 25(OH)D <subscript>3</subscript> was inversely associated with poor mental health at baseline (odds ratio (OR) for 10 nmol/l increase in 25(OH)D <subscript>3</subscript> , 0.90 (95% confidence interval (CI) 0.83-0.96, p = 0.003)) but not at follow-up (p > 0.05). Serum 25(OH)D <subscript>3</subscript> was not associated with vitality at baseline (p > 0.05). At follow-up, there was an inverse association between 25(OH)D <subscript>3</subscript> and low vitality (OR for 10 nmol/l increase in 25(OH)D <subscript>3</subscript> , 0.89 (95% CI 0.82-0.97, p = 0.009)) but not after adjustment.<br />Conclusion: We found an inverse association between 25(OH)D <subscript>3</subscript> and mental health in patients with T2D at baseline. We found no association between 25(OH)D <subscript>3</subscript> and vitality after adjustment. Future studies are needed to determine the association between vitamin D and mental well-being in patients with T2D.

Details

Language :
English
ISSN :
2520-8721
Volume :
19
Issue :
3
Database :
MEDLINE
Journal :
Hormones (Athens, Greece)
Publication Type :
Academic Journal
Accession number :
32440752
Full Text :
https://doi.org/10.1007/s42000-020-00190-1