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A self-adhesive microneedle patch with drug loading capability through swelling effect.

Authors :
Chew SWT
Shah AH
Zheng M
Chang H
Wiraja C
Steele TWJ
Xu C
Source :
Bioengineering & translational medicine [Bioeng Transl Med] 2020 Feb 29; Vol. 5 (2), pp. e10157. Date of Electronic Publication: 2020 Feb 29 (Print Publication: 2020).
Publication Year :
2020

Abstract

Microneedles (MNs) offer a rapid method of transdermal drug delivery through penetration of the stratum corneum. However, commercial translation has been limited by fabrication techniques unique to each drug. Herein, a broadly applicable platform is explored by drug-loading via swelling effect of a hydrogel MN patch. A range of small molecule hydrophilic, hydrophobic, and biomacromolecule therapeutics demonstrate successful loading and burst release from hydrogel MNs fabricated from methacrylated hyaluronic acid (MeHA). The post-fabrication drug loading process allows MeHA MN patches with drug loadings of 10 μg cm <superscript>-2</superscript> . Additional post-fabrication processes are explored with dendrimer bioadhesives that increase work of adhesion, ensuring stable fixation on skin, and allow for additional drug loading strategies.<br />Competing Interests: 6The authors declare no conflict of interest.<br /> (© 2020 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals, Inc. on behalf of The American Institute of Chemical Engineers.)

Details

Language :
English
ISSN :
2380-6761
Volume :
5
Issue :
2
Database :
MEDLINE
Journal :
Bioengineering & translational medicine
Publication Type :
Academic Journal
Accession number :
32440562
Full Text :
https://doi.org/10.1002/btm2.10157