Oxidation of 8-thioguanosine gives redox-responsive hydrogels and reveals intermediates in a desulfurization pathway.

Authors :: Xiao S
Lee W
Chen F
Zavalij PY
Gutierrez O
Davis JT
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 Jun 25; Vol. 56 (51), pp. 6981-6984.
Publication Year :: 2020
Abstract: A disulfide made by oxidation of 8-thioguanosine is a supergelator. The hydrogels are redox-responsive, as they disassemble upon either reduction or oxidation of the S-S bond. We also identified this disulfide, and 2 other compounds, as intermediates in oxidative desulfurization of 8-thioG to guanosine.

Subjects :: Density Functional Theory
Guanosine chemistry
Molecular Structure
Oxidation-Reduction
Disulfides chemistry
Guanosine analogs & derivatives
Hydrogels chemistry
Thionucleosides chemistry

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