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Primary Cutaneous CD30+ Lymphoproliferative Disorders: a Comprehensive Review.
- Source :
-
Current hematologic malignancy reports [Curr Hematol Malig Rep] 2020 Aug; Vol. 15 (4), pp. 333-342. - Publication Year :
- 2020
-
Abstract
- Purpose of Review: Primary cutaneous CD30+ T-cell lymphoproliferative disorders (CD30+ LPDs) are the second most common cutaneous lymphomas after mycosis fungoides and Sezary syndrome. They include primary cutaneous anaplastic large cell lymphoma (pcALCL), lymphomatoid papulosis (LyP), and borderline lesions. The purpose of this literature review is to consolidate the available evidence on the primary cutaneous CD30+ LPD in order to define the tools for correct diagnosis and appropriate treatment.<br />Recent Findings: The current body of knowledge regarding the clinical features, histopathologic changes, recently described genetic alterations, and therapeutic options will be covered in this comprehensive review. Primary cutaneous CD30+ LPD represent rare cutaneous lymphomas that have significant histologic overlap within the defined group as well as with other neoplastic and reactive entities. The importance of differentiating these entities is crucial, as each one has a different clinical course and prognosis.
- Subjects :
- Diagnosis, Differential
Humans
Predictive Value of Tests
Prognosis
Ki-1 Antigen immunology
Lymphoma, Primary Cutaneous Anaplastic Large Cell genetics
Lymphoma, Primary Cutaneous Anaplastic Large Cell immunology
Lymphoma, Primary Cutaneous Anaplastic Large Cell therapy
Lymphomatoid Papulosis genetics
Lymphomatoid Papulosis immunology
Lymphomatoid Papulosis therapy
Lymphoproliferative Disorders genetics
Lymphoproliferative Disorders immunology
Lymphoproliferative Disorders therapy
Skin Neoplasms genetics
Skin Neoplasms immunology
Skin Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1558-822X
- Volume :
- 15
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Current hematologic malignancy reports
- Publication Type :
- Academic Journal
- Accession number :
- 32435988
- Full Text :
- https://doi.org/10.1007/s11899-020-00583-4