Cellulose nanocrystals of variable sulfation degrees can sequester specific platelet lysate-derived biomolecules to modulate stem cell response.

Authors :: Mendes BB
Gómez-Florit M
Osório H
Vilaça A
Domingues RMA
Reis RL
Gomes ME
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 Jun 25; Vol. 56 (50), pp. 6882-6885. Date of Electronic Publication: 2020 May 21.
Publication Year :: 2020
Abstract: The surface chemistry of cellulose nanocrystals was engineered to show variable sulfation degrees, which was exploited to modulate platelet lysate-derived biomolecule sequestration and presentation. The protein coronas developed on CNC surfaces were characterized and it was demonstrated how they promote different signaling effects on human adipose-derived stem cell behavior.

Subjects :: Blood Platelets
Cells, Cultured
Cellulose chemistry
Humans
Hydrolysis
Nanoparticles chemistry
Sulfuric Acids chemistry
Surface Properties
Adipose Tissue cytology
Cellulose administration & dosage
Nanoparticles administration & dosage
Protein Corona chemistry
Stem Cells drug effects

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