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High-dose influenza vaccination and mortality among predominantly male, white, senior veterans, United States, 2012/13 to 2014/15.
- Source :
-
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin [Euro Surveill] 2020 May; Vol. 25 (19). - Publication Year :
- 2020
-
Abstract
- IntroductionIt is unclear whether high-dose influenza vaccine (HD) is more effective at reducing mortality among seniors.AimThis study aimed to evaluate the relative vaccine effectiveness (rVE) of HD. MethodsWe linked electronic medical record databases in the Veterans Health Administration (VHA) and Medicare administrative files to examine the rVE of HD vs standard-dose influenza vaccines (SD) in preventing influenza/pneumonia-associated and cardiorespiratory mortality among VHA-enrolled veterans 65 years or older during the 2012/13, 2013/14 and 2014/15 influenza seasons. A multivariable Cox proportional hazards model was performed on matched recipients of HD vs SD, based on vaccination time, location, age, sex, ethnicity and VHA priority level. ResultsAmong 569,552 person-seasons of observation, 207,574 (36%) were HD recipients and 361,978 (64%) were SD recipients, predominantly male (99%) and white (82%). Pooling findings from all three seasons, the adjusted rVE estimate of HD vs SD during the high influenza periods was 42% (95% confidence interval (CI): 24-59) against influenza/pneumonia-associated mortality and 27% (95% CI: 23-32) against cardiorespiratory mortality. Residual confounding was evident in both early and late influenza periods despite matching and multivariable adjustment. Excluding individuals with high 1-year predicted mortality at baseline reduced the residual confounding and yielded rVE of 36% (95% CI: 10-62) and 25% (95% CI: 12-38) against influenza/pneumonia-associated and cardiorespiratory mortality, respectively. These were confirmed by results from two-stage residual inclusion estimations.DiscussionThe HD was associated with a lower risk of influenza/pneumonia-associated and cardiorespiratory death in men during the high influenza period.
- Subjects :
- Aged
Aged, 80 and over
Dose-Response Relationship, Drug
Drug-Related Side Effects and Adverse Reactions
Electronic Health Records
Humans
Influenza Vaccines adverse effects
Influenza Vaccines immunology
Influenza, Human ethnology
Male
Medicare
Pneumonia ethnology
Seasons
Survival Analysis
United States epidemiology
Vaccination methods
Vaccination mortality
White People
Influenza Vaccines administration & dosage
Influenza, Human mortality
Influenza, Human prevention & control
Pneumonia mortality
Pneumonia prevention & control
Veterans statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1560-7917
- Volume :
- 25
- Issue :
- 19
- Database :
- MEDLINE
- Journal :
- Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 32431290
- Full Text :
- https://doi.org/10.2807/1560-7917.ES.2020.25.19.1900401