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Excitation-inhibition balance and auditory multistable perception are correlated with autistic traits and schizotypy in a non-clinical population.
- Source :
-
Scientific reports [Sci Rep] 2020 May 18; Vol. 10 (1), pp. 8171. Date of Electronic Publication: 2020 May 18. - Publication Year :
- 2020
-
Abstract
- Individuals with autism spectrum disorder and individuals with schizophrenia have impaired social and communication skills. They also have altered auditory perception. This study investigated autistic traits and schizotypy in a non-clinical population as well as the excitation-inhibition (EI) balance in different brain regions and their auditory multistable perception. Thirty-four healthy participants were assessed by the Autism-Spectrum Quotient (AQ) and Schizotypal Personality Questionnaire (SPQ). The EI balance was evaluated by measuring the resting-state concentrations of glutamate-glutamine (Glx) and ϒ-aminobutyric acid (GABA) in vivo by using magnetic resonance spectroscopy. To observe the correlation between their traits and perception, we conducted an auditory streaming task and a verbal transformation task, in which participants reported spontaneous perceptual switching while listening to a sound sequence. Their AQ and SPQ scores were positively correlated with the Glx/GABA ratio in the auditory cortex but not in the frontal areas. These scores were negatively correlated with the number of perceptual switches in the verbal transformation task but not in the auditory streaming task. Our results suggest that the EI balance in the auditory cortex and the perceptual formation of speech are involved in autistic traits and schizotypy.
- Subjects :
- Adolescent
Adult
Auditory Cortex diagnostic imaging
Auditory Cortex metabolism
Autism Spectrum Disorder diagnostic imaging
Autism Spectrum Disorder metabolism
Child
Female
Glutamic Acid metabolism
Glutamine metabolism
Humans
Inhibition, Psychological
Male
Schizophrenia
Schizotypal Personality Disorder diagnostic imaging
Schizotypal Personality Disorder metabolism
Verbal Learning
Young Adult
Auditory Perception
Autism Spectrum Disorder psychology
Schizotypal Personality Disorder psychology
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 32424307
- Full Text :
- https://doi.org/10.1038/s41598-020-65126-6