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Ethanol extract of Pycnoporus sanguineus relieves the dextran sulfate sodium-induced experimental colitis by suppressing helper T cell-mediated inflammation via apoptosis induction.
- Source :
-
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 Jul; Vol. 127, pp. 110212. Date of Electronic Publication: 2020 May 11. - Publication Year :
- 2020
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Abstract
- Inflammatory bowel disease (IBD) is a chronic relapsing inflammation involving the gut system, and disequilibrium of T helper (Th) cell paradigm has been recognized as critical pathogenesis. Pycnoporus sanguineus (L.) Murrill is a species of the white-rot basidiomycetes listed as food- and cosmetic-grade microorganisms. In this study, anti-inflammatory activity of the ethanol extract from P. sanguineus (PSE) was investigated in dextran sulfate sodium (DSS)-induced experimental colitis model. PSE recovered the DSS-caused weight loss, reversed the colon shortening, and ameliorated the histopathological lesion in colon, resulting in lower disease activity index (DAI). Levels of serumal lipopolysaccharide (LPS), colonic myeloperoxidase (MPO) in the colitis-suffering mice were declined by PSE treatment. PSE also improved the mucosal integrity by enhancing the expression of tight junction and adherens junction proteins in the colon, including ZO-1, occludin, claudin-1, and E-cadherin. Besides, PSE reduced helper T cells (Th) in the colon, together with an evident decrease of several Th cell-related cytokines. Moreover, it was found that in vitro, PSE suppressed T cells and the Th subset upon Concanavalin A (ConA)-stimulation by inducing apoptosis. In summary, PSE displayed a remission on the colitis-related inflammation, which would possibly rely on the epithelial barrier restoration by suppressing Th cells via apoptosis induction, highlighting a promising potential in the treatment for IBD.<br />Competing Interests: Declaration of Competing Interest Author Shunxian Li and Yizhen Xie were employed by Guangdong Yuewei Edible Fungi Technology Co. Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2020 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.)
- Subjects :
- Animals
Anti-Inflammatory Agents isolation & purification
Anti-Inflammatory Agents pharmacology
Apoptosis drug effects
Colitis pathology
Cytokines metabolism
Dextran Sulfate toxicity
Disease Models, Animal
Ethanol chemistry
Inflammation pathology
Inflammatory Bowel Diseases drug therapy
Inflammatory Bowel Diseases pathology
Male
Mice
Mice, Inbred BALB C
T-Lymphocytes, Helper-Inducer immunology
Colitis drug therapy
Inflammation drug therapy
Plant Extracts pharmacology
Polyporaceae chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1950-6007
- Volume :
- 127
- Database :
- MEDLINE
- Journal :
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- Publication Type :
- Academic Journal
- Accession number :
- 32422567
- Full Text :
- https://doi.org/10.1016/j.biopha.2020.110212