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Design of nanostructure chitosan hydrogels for carrying zinc phthalocyanine as a photosensitizer and difloxacin as an antibacterial agent.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2020 Sep 15; Vol. 159, pp. 598-606. Date of Electronic Publication: 2020 May 16. - Publication Year :
- 2020
-
Abstract
- Here, we develop homogeneous hydrogel networks containing zinc tetraamino-phthalocyanine (ZnTAPc) as photosensitizer cross-linked with glutaraldehyde. The cross-linking process occurs via imine bond formation by reaction of NH <subscript>2</subscript> groups of ZnTAPc and chitosan with aldehyde groups of the glutaraldehyde. Insertion of ZnTAPc interestingly increases its solubility in water medium. 2.0% and 4% w/w of the ZnTAPc were used with respect to chitosan polymer to generate hydrogel photosensitizer. FT-IR and UV-Vis spectroscopy, scanning electron microscopy, and rheological measurements were applied to evaluate the properties of the prepared hydrogels. Finally, difloxacin HCl was selected as a fluoroquinolone drug for the assessment of the drug release features of the made hydrogels. The difloxacin release was affected by the amount of ZnTAPc and pH medium. The activity of the hydrogels in photosensitizing process was considered by computing the rate of 1,3-diphenylisobenzofuran adsorption reduction as a singlet oxygen chemical quencher.<br />Competing Interests: Declaration of competing interest None.<br /> (Copyright © 2020. Published by Elsevier B.V.)
- Subjects :
- Anti-Bacterial Agents chemistry
Chemistry Techniques, Synthetic
Ciprofloxacin administration & dosage
Ciprofloxacin chemistry
Drug Delivery Systems
Drug Liberation
Indoles chemical synthesis
Indoles chemistry
Isoindoles
Molecular Structure
Organometallic Compounds chemical synthesis
Organometallic Compounds chemistry
Photosensitizing Agents chemical synthesis
Photosensitizing Agents chemistry
Rheology
Solubility
Spectroscopy, Fourier Transform Infrared
Temperature
Zinc Compounds
Anti-Bacterial Agents administration & dosage
Chitosan chemistry
Ciprofloxacin analogs & derivatives
Drug Carriers chemistry
Hydrogels chemistry
Indoles administration & dosage
Organometallic Compounds administration & dosage
Photosensitizing Agents administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 159
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 32422258
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2020.05.086