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Eyes absent in the cockroach panoistic ovaries regulates proliferation and differentiation through ecdysone signalling.

Authors :
Ramos S
Chelemen F
Pagone V
Elshaer N
Irles P
Piulachs MD
Source :
Insect biochemistry and molecular biology [Insect Biochem Mol Biol] 2020 Aug; Vol. 123, pp. 103407. Date of Electronic Publication: 2020 May 15.
Publication Year :
2020

Abstract

Eyes absent (Eya), is a protein structurally conserved from hydrozoans to humans, for which two basic roles have been reported: it can act as a transcription cofactor and as a protein tyrosine phosphatase. Eya was discovered in the fly Drosophila melanogaster in relation to its function in eye development, and the same function was later reported in other insects. Eya is also involved in insect oogenesis, although studies in this sense are limited to D. melanogaster, which has meroistic ovaries, and where eya mutations abolish gonad formation. In the present work we studied the function of eya in the panoistic ovary of the cockroach Blattella germanica. We show that eya is essential for correct development of panoistic ovaries. In B. germanica, eya acts at different level and in a distinct way in the germarium and the vitellarium. In the germarium, eya contributes to maintain the correct number of somatic and germinal cells by regulating the expression of steroidogenic genes in the ovary. In the vitellarium, eya facilitates follicle cells proliferation and contributes to regulate the cell program, in the context of basal ovarian follicle maturation. Thus, eya-depleted females of B. germanica arrest the growth and maturation of basal ovarian follicles and become sterile.<br /> (Copyright © 2020 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1879-0240
Volume :
123
Database :
MEDLINE
Journal :
Insect biochemistry and molecular biology
Publication Type :
Academic Journal
Accession number :
32417417
Full Text :
https://doi.org/10.1016/j.ibmb.2020.103407