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Rewired Cas9s with Minimal Sequence Constraints.
- Source :
-
Trends in pharmacological sciences [Trends Pharmacol Sci] 2020 Jul; Vol. 41 (7), pp. 429-431. Date of Electronic Publication: 2020 May 13. - Publication Year :
- 2020
-
Abstract
- The genome editing toolkit is ever expanding. Although CRISPR-Cas systems can target virtually any gene, single-nucleotide resolution is yet to be achieved. Walton and colleagues engineered nucleases and base editors compatible with every protospacer adjacent motif (PAM) to achieve high-precision targeting. Their findings revealed the striking plasticity of Cas9.<br /> (Copyright © 2020 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1873-3735
- Volume :
- 41
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Trends in pharmacological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 32416935
- Full Text :
- https://doi.org/10.1016/j.tips.2020.04.009