Chitosan hybrid microgels for oral drug delivery.

Authors :: Galdioli Pellá MC
Simão AR
Lima-Tenório MK
Tenório-Neto E
Scariot DB
Nakamura CV
Rubira AF
Source :: Carbohydrate polymers [Carbohydr Polym] 2020 Jul 01; Vol. 239, pp. 116236. Date of Electronic Publication: 2020 Apr 09.
Publication Year :: 2020
Abstract: In the present work, hybrid microgels based on chitosan and SiO <subscript>2</subscript> nanoparticles (NPs) were synthesized. Both chitosan and the SiO <subscript>2</subscript> NPs were submitted to chemical modification reactions to having vinyl groups incorporated into their structures. The microgels were synthesized by emulsion polymerization. SEM analysis indicated a high dispersity of diameter for the microgels, ranging between (18.7 ± 12.3) μm for the samples without SiO <subscript>2</subscript> -VTS and (11.3 ± 8.07) μm for the microgels with SiO <subscript>2</subscript> -VTS. The material showed pH-responsiveness, especially in acidic pHs. The longest release lasted 45 min and large amounts of drugs were released as soon as the material was added to the release medium. It is interesting for oral drug delivery systems, especially for gastric wound treatment. The fast release of high amounts of drugs promotes an immediate relief of the pain and the following controlled release allows the gradual recovery of the damaged area.<br /> (Copyright © 2020 Elsevier Ltd. All rights reserved.)