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RNA-Binding Proteins in Acute Leukemias.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2020 May 12; Vol. 21 (10). Date of Electronic Publication: 2020 May 12. - Publication Year :
- 2020
-
Abstract
- Acute leukemias are genetic diseases caused by translocations or mutations, which dysregulate hematopoiesis towards malignant transformation. However, the molecular mode of action is highly versatile and ranges from direct transcriptional to post-transcriptional control, which includes RNA-binding proteins (RBPs) as crucial regulators of cell fate. RBPs coordinate RNA dynamics, including subcellular localization, translational efficiency and metabolism, by binding to their target messenger RNAs (mRNAs), thereby controlling the expression of the encoded proteins. In view of the growing interest in these regulators, this review summarizes recent research regarding the most influential RBPs relevant in acute leukemias in particular. The reported RBPs, either dysregulated or as components of fusion proteins, are described with respect to their functional domains, the pathways they affect, and clinical aspects associated with their dysregulation or altered functions.
- Subjects :
- Acute Disease
Animals
Humans
Leukemia metabolism
Nucleic Acid Conformation
Protein Binding
Protein Domains
RNA, Messenger chemistry
RNA, Messenger metabolism
RNA-Binding Proteins chemistry
RNA-Binding Proteins metabolism
Gene Expression Regulation, Leukemic
Leukemia genetics
RNA, Messenger genetics
RNA-Binding Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 21
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 32408494
- Full Text :
- https://doi.org/10.3390/ijms21103409