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Structure-Dependent Antibacterial Activity of Amino Acid-Based Supramolecular Hydrogels.
- Source :
-
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2020 Sep; Vol. 193, pp. 111099. Date of Electronic Publication: 2020 May 05. - Publication Year :
- 2020
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Abstract
- Bacterial infections are currently a major concern to human health. Amino acid-based supramolecular polymer hydrogels, which boast intrinsic antibacterial activity, are an important solution due to their good biocompatibility, cost effectiveness, and tunable structural properties. Herein, we reported three types of transparent supramolecular hydrogel with intrinsic antibacterial activity from self-assembly of commercially available Fmoc-tryptophan (Fmoc-W), Fmoc-methionine (Fmoc-M), and Fmoc-tyrosine (Fmoc-Y). The resulting hydrogels selectively inhibited the growth of Gram-positive bacteria. Moreover, the order of antibacterial activity was Fmoc-W hydrogel > Fmoc-M hydrogel > Fmoc-Y hydrogel. The critical aggregation concentration (CAC) values were found at concentrations of approximately 0.0293, 0.1172, and 0.4688 mM for Fmoc-W, Fmoc-M, and Fmoc-Y, respectively. Transmission electron microscope (TEM) images revealed rigid and aligned nanofibers for Fmoc-W hydrogel, while flexible nanofibers for Fmoc-M hydrogel and Fmoc-Y hydrogel. The results indicated that stronger aggregation capability of the gelator and the synergistic nanostructural morphology with more rigid and aligned nanofibers can lead to higher antibacterial activity of its corresponding hydrogel. In addition, the molecular arrangements of Fmoc-amino acids in the hydrogels may also contribute to their antibacterial activity. These results can guide the rational design, fabrication, and future application of other self-assembled amino acid-based hydrogels with excellent antibacterial activity.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- Amino Acids chemistry
Anti-Bacterial Agents chemistry
Hydrogels chemistry
Macromolecular Substances chemistry
Macromolecular Substances pharmacology
Microbial Sensitivity Tests
Molecular Structure
Particle Size
Surface Properties
Amino Acids pharmacology
Anti-Bacterial Agents pharmacology
Gram-Negative Bacteria drug effects
Gram-Positive Bacteria drug effects
Hydrogels pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4367
- Volume :
- 193
- Database :
- MEDLINE
- Journal :
- Colloids and surfaces. B, Biointerfaces
- Publication Type :
- Academic Journal
- Accession number :
- 32408261
- Full Text :
- https://doi.org/10.1016/j.colsurfb.2020.111099