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Oxidative red blood cell damage associated with propofol and intravenous lipid emulsion therapy in a dog treated for 5-fluorouracil toxicosis.
- Source :
-
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) [J Vet Emerg Crit Care (San Antonio)] 2020 Jul; Vol. 30 (4), pp. 481-486. Date of Electronic Publication: 2020 May 14. - Publication Year :
- 2020
-
Abstract
- Objective: To describe the first documented case of oxidant-induced anemia in a dog associated with propofol and IV lipid emulsion (IVLE) treatment for 5-fluorouracil (5-FU) toxicosis.<br />Case Summary: A 2-year-old male intact mixed breed dog was presented for evaluation after ingestion of 5% 5-FU cream. Refractory reactive seizures rapidly developed, and treatment with benzodiazepines, propofol, levetiracetam, and IVLE was initiated. The dog was euthanized due to development of marked oxidant-induced anemia.<br />New Information Provided: This report documents the first instance of oxidant-induced anemia in the dog, associated with propofol and IVLE infusion therapy prescribed for treatment of 5-FU toxicosis.<br /> (© Veterinary Emergency and Critical Care Society 2020.)
- Subjects :
- Animals
Antimetabolites toxicity
Dog Diseases therapy
Dogs
Fat Emulsions, Intravenous therapeutic use
Hypnotics and Sedatives adverse effects
Hypnotics and Sedatives therapeutic use
Levetiracetam therapeutic use
Male
Propofol therapeutic use
Dog Diseases chemically induced
Erythrocytes drug effects
Fat Emulsions, Intravenous adverse effects
Fluorouracil toxicity
Oxidative Stress drug effects
Propofol adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1476-4431
- Volume :
- 30
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
- Publication Type :
- Academic Journal
- Accession number :
- 32407575
- Full Text :
- https://doi.org/10.1111/vec.12958