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Clinical Characteristic and Outcomes of BK Virus Infection in Kidney Transplant Recipients Managed Using a Systematic Surveillance and Treatment Strategy.
- Source :
-
Transplantation proceedings [Transplant Proc] 2020 Jul - Aug; Vol. 52 (6), pp. 1749-1756. Date of Electronic Publication: 2020 May 10. - Publication Year :
- 2020
-
Abstract
- Background: BK virus (BKV)-associated nephropathy is a significant complication of kidney transplantation that progresses to graft dysfunction and graft loss. The aim of this study was to know the infection rate and progression of BKV according to our strategy.<br />Materials and Methods: This study included 302 patients who received kidney transplantation between August 2010 and October 2012. Patients were divided into 4 groups: no BK infection, BK viruria only, low BK viremia, and high BK viremia.<br />Results: In this study, 57 patients had BK viremia (18.9%), and 18 patients had BK nephropathy (5.9%) during a 2-year follow-up period. Age, sex, cytomegalovirus (CMV) viremia, existence of donor-specific antibodies, type of transplantation, and delayed graft function were not significantly different. Disappearance of BKV infection was better in the viruria and low viremia groups than in the high viremia group (P = .001), and duration of BK infection was longer in the high viremia group than the low viremia group (P = .002).<br />Conclusion: All diagnosed cases of BKV nephropathy were in the high BK viremia group. For BK viruria and viremia, early detection of BK infection together with early intervention by reduced immunosuppressant is a useful strategy to maintain allograft function. Long-term follow up is required to identify the risk factors for BK infection and graft survival after kidney transplantation.<br /> (Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Female
Graft Survival immunology
Humans
Kidney Diseases virology
Kidney Transplantation adverse effects
Male
Middle Aged
Polyomavirus Infections virology
Postoperative Complications virology
Risk Factors
Tumor Virus Infections virology
Viremia virology
BK Virus
Immunosuppressive Agents adverse effects
Kidney Diseases chemically induced
Polyomavirus Infections chemically induced
Postoperative Complications chemically induced
Tumor Virus Infections chemically induced
Viremia chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2623
- Volume :
- 52
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Transplantation proceedings
- Publication Type :
- Academic Journal
- Accession number :
- 32402452
- Full Text :
- https://doi.org/10.1016/j.transproceed.2020.01.158