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New insights into the potential mechanisms of spermatogenic failure in patients with idiopathic azoospermia.
- Source :
-
Molecular human reproduction [Mol Hum Reprod] 2020 Jul 01; Vol. 26 (7), pp. 469-484. - Publication Year :
- 2020
-
Abstract
- Idiopathic azoospermia (IA) refers to azoospermia without a clear aetiology. Due to the unclear aetiology and pathological mechanism of IA, there is no effective treatment for IA. The development of assisted reproductive and microsperm extraction technologies has brought hope to patients with IA with fertility problems. However, there are still many patients with IA whose testes lack healthy sperm, causing infertility. Therefore, it is key to identify how testicular spermatogenic failure can be reversed to promote spermatogenesis in patients with IA to resolve fertility problems; these goals are a great challenge in reproductive medicine. The underlying genetic factors seem to be important pathological factors of IA. Understanding the role of genetic factors in the pathological mechanism of spermatogenic failure in patients with IA is of great value for future studies and treatments and is also an important reference for the reproductive health of males and their offspring. A method combining sequencing technology and bioinformatics analysis is an important means to understand the genetic pathological mechanisms. We used bioinformatics analysis to study the public human IA dataset. We found that the pathogenic mechanism of IA may be related to abnormal ciliary structure and function and disrupted RNA metabolism in spermatogenic cells. Disrupted m6A regulation of spermatogenesis may be an important pathological mechanism of IA and warrants attention. Finally, we screened for key genes and potential therapeutic drugs to determine future research directions.<br /> (© The Author(s) 2020. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
- Subjects :
- Chromosomes, Human, Y metabolism
Computational Biology
Humans
Male
Quantitative Trait Loci genetics
Spermatogenesis genetics
Spermatozoa physiology
Azoospermia metabolism
Chromosomes, Human, Y physiology
Infertility, Male metabolism
Infertility, Male physiopathology
Spermatogenesis physiology
Spermatozoa metabolism
Testis metabolism
Testis physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2407
- Volume :
- 26
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Molecular human reproduction
- Publication Type :
- Academic Journal
- Accession number :
- 32402059
- Full Text :
- https://doi.org/10.1093/molehr/gaaa033