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Measurement and characterization of distinctive clinical phenotypes using the Frontotemporal Lobar Degeneration Module (FTLD-MOD).
- Source :
-
Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2020 Jun; Vol. 16 (6), pp. 918-925. Date of Electronic Publication: 2020 May 13. - Publication Year :
- 2020
-
Abstract
- Introduction: The Frontotemporal Lobar Degeneration Module (FTLD-MOD) was designed as a research neuropsychological battery to evaluate clinical symptoms associated with FTLD. This study investigated whether the FTLD-MOD could differentiate between primary progressive aphasia (PPA) and behavioral variant frontotemporal dementia (bvFTD), two distinct FTLD-related syndromes.<br />Methods: Retrospective analysis was conducted on data collected from the initial visit of 165 subjects with PPA, 268 with bvFTD, and 251 cognitively normal controls from the National Alzheimer's Coordinating Center. Generalized linear models were used to compare group performance patterns on FTLD-MOD tasks of language, behavior, and memory.<br />Results: PPA participants showed significantly poorer performances on all language tasks whereas bvFTD participants demonstrated poorer performances on most behavioral measures. There were no differences in memory performances. Descriptive data on participant groups are provided for reference.<br />Discussion: Findings from this multi-center sample suggest that the FTLD-MOD can differentiate between distinctive clinical phenotypes commonly associated with FTLD.<br /> (© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.)
- Subjects :
- Adult
Aged
Aphasia, Primary Progressive psychology
Diagnosis, Differential
Female
Frontotemporal Dementia psychology
Frontotemporal Lobar Degeneration psychology
Humans
Male
Middle Aged
Neuropsychological Tests
Retrospective Studies
Aphasia, Primary Progressive diagnosis
Cognition physiology
Frontotemporal Dementia diagnosis
Frontotemporal Lobar Degeneration diagnosis
Language
Memory physiology
Phenotype
Subjects
Details
- Language :
- English
- ISSN :
- 1552-5279
- Volume :
- 16
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Alzheimer's & dementia : the journal of the Alzheimer's Association
- Publication Type :
- Academic Journal
- Accession number :
- 32400973
- Full Text :
- https://doi.org/10.1002/alz.12098