Back to Search
Start Over
3D-Printed Coronary Implants Are Effective for Percutaneous Creation of Swine Models with Focal Coronary Stenosis.
- Source :
-
Journal of cardiovascular translational research [J Cardiovasc Transl Res] 2020 Dec; Vol. 13 (6), pp. 1033-1043. Date of Electronic Publication: 2020 May 11. - Publication Year :
- 2020
-
Abstract
- Reliable, closed-chest methods for creating large animal models of acute myocardial hypoperfusion are limited. We demonstrated the feasibility and efficacy of using magnetic resonance (MR)-compatible 3D-printed coronary implants for establishing swine models of myocardial hypoperfusion. We designed, manufactured, and percutaneously deployed implants in 13 swine to selectively create focal coronary stenosis. To test the efficacy of the implants to cause hypoperfusion or ischemia in the perfused territory, we evaluated regional wall motion, myocardial perfusion, and infarction using MR imaging. The overall swine survival rate was 85% (11 of 13). The implant retrieval rate was 92% (12 of 13). Fluoroscopic angiography confirmed focal stenosis. Cine and perfusion MRI showed regional wall motion abnormalities and inducible ischemia, respectively. Late gadolinium enhancement and histopathology showed no myocardial infarction. Our minimally invasive technique has promising applications for validation of new diagnostic methods in cardiac MR. Graphical abstract Our new minimally invasive, percutaneous method for creating swine models of acute focal coronary stenosis can be used for magnetic resonance imaging studies of myocardial ischemia. Comparable to existing methods in its efficacy and reliability, this rapid prototyping technique will allow researchers to more easily conduct translational cardiac imaging studies of coronary artery disease in large animal models.
- Subjects :
- Animals
Coronary Circulation
Coronary Stenosis diagnostic imaging
Coronary Stenosis physiopathology
Disease Models, Animal
Feasibility Studies
Magnetic Resonance Imaging, Cine
Male
Myocardial Infarction diagnostic imaging
Myocardial Infarction physiopathology
Myocardial Perfusion Imaging
Proof of Concept Study
Sus scrofa
Coronary Stenosis etiology
Myocardial Infarction etiology
Printing, Three-Dimensional
Prosthesis Design
Prosthesis Implantation instrumentation
Subjects
Details
- Language :
- English
- ISSN :
- 1937-5395
- Volume :
- 13
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of cardiovascular translational research
- Publication Type :
- Academic Journal
- Accession number :
- 32394352
- Full Text :
- https://doi.org/10.1007/s12265-020-10018-3