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Cardioprotective effects of timosaponin B-II isolated from Anemarrhena rhizome in a zebrafish model.
- Source :
-
Die Pharmazie [Pharmazie] 2020 May 01; Vol. 75 (5), pp. 201-204. - Publication Year :
- 2020
-
Abstract
- Timosaponin B-II (TB-II; (25S)-26-(β-D-glucopyranosyloxy)-3β-[(2-O-β-D-glucopyranosyl-β-D-galactopyranosyl) oxy]-5β-furostan-22-ol is extracted from Anemarrhena . Its anti-inflammation, anti-oxidation, and anti-asthma properties have been widely explored. However, its effect on the heart has not been reported. In this study, we used zebrafish as a research model to determine the effects of TB-II on the heart and its toxic and anti-inflammatory effects. To explore the cause of cardioprotective effects of TB-II, we used transgenic zebrafish with macrophages and neutrophils labeled with fluorescent protein. We found for the first time that TB-II had a protective effect on the zebrafish heart. It did not affect the survival and hatching rates of zebrafish embryos, indicating its low toxicity. Results showed that TB-II may have cardioprotective effects, which might be related to its anti-inflammatory effects.
- Subjects :
- Animals
Animals, Genetically Modified
Anti-Inflammatory Agents administration & dosage
Anti-Inflammatory Agents isolation & purification
Cardiotonic Agents isolation & purification
Cardiotonic Agents toxicity
Female
Macrophages drug effects
Macrophages metabolism
Male
Neutrophils drug effects
Neutrophils metabolism
Rhizome
Saponins isolation & purification
Saponins toxicity
Steroids isolation & purification
Steroids toxicity
Zebrafish
Anemarrhena chemistry
Anti-Inflammatory Agents pharmacology
Cardiotonic Agents pharmacology
Saponins pharmacology
Steroids pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0031-7144
- Volume :
- 75
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Die Pharmazie
- Publication Type :
- Academic Journal
- Accession number :
- 32393429
- Full Text :
- https://doi.org/10.1691/ph.2020.9869