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Potential through simplicity: thymidine kinase-1 as a biomarker for CDK4/6 inhibitors.
- Source :
-
British journal of cancer [Br J Cancer] 2020 Jul; Vol. 123 (2), pp. 176-177. Date of Electronic Publication: 2020 May 08. - Publication Year :
- 2020
-
Abstract
- We describe a potential role for thymidine kinase-1, a general marker of cellular proliferation, to act as a prognostic biomarker in patients receiving CDK4/6 inhibitors for advanced hormone receptor-positive, HER2-negative breast cancer, with early data suggesting that it may also provide early indication of treatment response.
- Subjects :
- Biomarkers, Tumor genetics
Breast Neoplasms genetics
Breast Neoplasms pathology
Cyclin-Dependent Kinase 4 genetics
Cyclin-Dependent Kinase 6 genetics
Female
Humans
Protein Kinase Inhibitors therapeutic use
Receptor, ErbB-2 genetics
Breast Neoplasms drug therapy
Cyclin-Dependent Kinase 4 antagonists & inhibitors
Cyclin-Dependent Kinase 6 antagonists & inhibitors
Thymidine Kinase genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1532-1827
- Volume :
- 123
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- British journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 32382111
- Full Text :
- https://doi.org/10.1038/s41416-020-0858-y